Inhibition Of Chitin Polymerization

Competitive inhibitors with structural resemblance to the substrate UDP-GlcNAc effectively block chitin polymerization and a few were commercialized as pest control agents. Some other compounds either directly or indirectly affect chitin polymerization to a certain degree. CS inhibition was studied using in vivo (whole organisms, isolated organs and integument tissues as well as cultured cells) or in vitro (cell-free preparations) systems. 8.1.1 Pyrimidine-nucleoside peptides Nucleoside peptide...

Structural and functional aspects

Chitin hardly occurs in pure form but rather as an integral element of various extracellular structures such as cuticles and PMs in arthropods or cells' walls in fungi. Chitin crystallites form a basic scaffold for the construction of such structures jointly with either extracellular proteins or polysaccharides in arthropod and fungal systems, respectively. Characteristics of the chito-protein interactions and the organization and length of chitin crystallites determine the architectures and...

Inhibitors Of Chitin Hydrolysis

Most of the inhibitors of family 18 chitinases are natural products that include diverse structurally unrelated compounds like pseudo-trisaccharides (allosami-dins), cyclic peptides (agrifin, argadin), alkaloids and methylxanthines (Andersen et al., 2005). Although quite potent, the majority of the compounds (except allosamidins) display broad inhibitory spectrum, which probably has posed limits to their development as pest control agents. The best known, and the most extensively investigated...