N-carboxybiotin biotin c02 + atp

Figure 3.4 Carbon dioxide, as HCOs is attached to biotin, and then transferred to acetyl coenzyme A forming malonyl coenzyme A for fatty acid synthesis from there to p-ketosynthase. Then condensation between acetate and malonate occurs, followed by reduction of the keto-group, dehydration of the alcohol and reduction of the double bond (Figure 3.5 Part B). The butyryl group thus formed moves to the (3-ketosynthase and is replaced by another molecule of malonate on ACP. Now condensation occurs again and the cycle continues (Figure 3.5 Part C). Note that the synthesis uses NADPH for reduction of a double bond, but the same a. Transfer from coenzyme A to enzymes and condensation

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